Isaac surrounded with Blue Flies after using Guppy's Head in the Binding of Isaac: Rebirth (BOIR)

Blue Flies are a type of Fly in The Binding of Isaac: Rebirth (TBOIR)

They orbit around the player and will fly towards an enemy that is nearby and damage it.

Strategy Guide/Tips[edit]

  • Guppy's Head is an item that summons blue flies for you.
  • Rotten Baby will send blue flies at enemies
  • You can also find Blue Flies in Red Chests
  • If you have The Mulligan you have a chance of spawning an attack fly whenever you damage an enemy

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