- Whenever you take damage that reduces you to less than one full heart, you get teleported to some random room in the same level.
- This item can save you at times but often it might not be useful for example if you are about to defeat a boss and you go down to half a heart and you get teleported away - the Boss's health will reset and you will have to fight him again from the beginning.
- You can drop this item by holding the "Drop" button. See: Binding of Isaac Rebirth: Keyboard Controls
Cursed Skull has the following Synergies and Interactions with other items:
|Dead Cat||You only have one red heart so you get teleported whenever you take damage (annoying synergy)|