"Kill Grandma's Attackers" is an objective in the quest To Grandmother's House We Go in Borderlands 2
Walkthrough[edit]
When you make it to Grandma's House you will see there are as number of bandits outside the house. Handsome Jack actually shows some concern about his Grandma. There are 5 Marauders outside that you need to gun down. Just keep moving and take each of them down in turn. It is not too hard to take them down.