"Makes Orphans Often" is a red text modifier on weapons in Borderlands 2
Found on the following red text weapon: Doc's Orphan Maker, (or any other version of the Orphan Makers Shotguns such as Captain Blades or Sidewinder) which you get for completing the "Message In A Bottle" mission in the Borderlands 2 DLC: Captain Scarlett and her Pirate's Booty
Grants Weapon Effects
Massive (850%) weapon damage bonus
Low pellet count Causes damage to user, 400~ per shot