"Take out the enemies" is an objective in the story mission The Third Way in Grand Theft Auto V.
Walkthrough[edit]
Once outside, Lamar is happy for the help from Franklin. Immediately start either firing on the van to the Northwest or pull out a Sticky Bomb/Grenade and lob it right at the Van. This will get the van to explode and take out at least a few of the enemies out here. You have a lot of FIB and Merryweather. Duck in and out of over to deal with the various enemies that are coming from the Northwest and North. Just keep fighting out here until you hear from Michael. At that point, change over to him.
